P-type ATPase

Preliminary study on mutations of the copper transporting P-type ATPase gene in the Chinese

中国人P型铜转运ATP酶基因突变的初步研究

The protein product belongs to the group of cation-transporting p-type ATPase ( ATP7B ) .

其蛋白产物为一铜转运P型ATP酶。

Objective To evaluate the effect of copper transporting P-type ATPase on hepatocyte ′ s copper metabolism and pathogenesis of Wilson disease ( WD ) .

【目的】探讨铜转运P型ATP酶在离体肝细胞铜代谢及Wilson病（WD）发病机制中的作用。

In plants , three distinct proton pumps generate proton electrochemical gradients across cell membranes : the P-type ATPase pumps , the vacuolar H + - ATPase and the vacuolar H + - pyrophosphatase .

在植物中三类不同的质子泵产生跨膜质子电化学梯度：质膜H~+-ATPase，液泡膜H~+-ATPase和液泡膜H~+-PPase。

As the Wilson disease ( WD ) is an autosomal recessive disorder caused by the deficiency of the P-type ATPase ( ATP7B ) . So molecular biological assay is helpful for differential diagnosis of pre-symptomatic WD patients and carriers .

肝豆状核变性病（Wilsondisease，WD）是由于P型ATP7B酶缺陷引起的常染色体隐性遗传性疾病，分子生物学方法有助于鉴别WD患者家系中症状前患者和杂合子。